Biopharmaceutics And Pharmacokinetics By Venkateswarlu Pdf
Biopharmaceutics and pharmacokinetics by venkateswarlu pdf
Biopharmaceutics and pharmacokinetics are two important disciplines in the field of pharmaceutical sciences. They deal with the factors that influence the therapeutic efficacy of a drug and the rates of movement of a drug and its metabolites in the body, respectively. A book that covers the basics of these two subjects is Biopharmaceutics and Pharmacokinetics by V. Venkateswarlu. This article will provide a brief overview of the book and its contents.
About the author
V. Venkateswarlu is a senior director at Dr.Reddy's Laboratories Ltd., Hyderabad, India. He has 27 years of teaching experience, including 12 years of postgraduate teaching, and 13 years of research experience. He has a M.Pharm. degree from Birla Institute of Technology, Ranchi, and a PhD degree from Kakatiya University, Warangal. He also received a post-doctoral fellowship from University of Georgia Athens, USA.
Biopharmaceutics and pharmacokinetics by venkateswarlu pdf
About the book
The book was first published in 2004 by B S Publishers and later revised and updated in 2015 by PharmaMed Press. The book has 530 pages and consists of 15 chapters. The book aims to provide a clear and concise explanation of the basic concepts and principles of biopharmaceutics and pharmacokinetics, with examples and practice problems. The book is intended for undergraduate and postgraduate students of pharmacy, as well as for professionals and researchers in the field.
Contents of the book
The book covers the following topics:
Introduction to biopharmaceutics: This chapter introduces the definition, scope, and objectives of biopharmaceutics, as well as the factors that affect the bioavailability and bioequivalence of drugs.
Physicochemical properties of drugs: This chapter discusses the importance of drug solubility, dissolution, partition coefficient, ionization, complexation, protein binding, and stability in biopharmaceutics.
Dosage form design: This chapter explains the role of dosage form design in drug delivery, absorption, distribution, metabolism, and excretion. It also describes the various types of dosage forms and their advantages and disadvantages.
Drug absorption: This chapter describes the mechanisms, routes, factors, models, methods, and kinetics of drug absorption.
Drug distribution: This chapter explains the concepts, factors, models, methods, and kinetics of drug distribution.
Drug metabolism: This chapter discusses the types, mechanisms, factors, methods, and kinetics of drug metabolism.
Drug excretion: This chapter covers the types, mechanisms, factors, methods, and kinetics of drug excretion.
Introduction to pharmacokinetics: This chapter introduces the definition, scope, objectives, assumptions, terminology, parameters, models, methods, and applications of pharmacokinetics.
One compartment open model: This chapter presents the most basic pharmacokinetic model in detail. It explains the equations for intravenous bolus injection, intravenous infusion, extravascular administration, multiple dosing, clearance, volume of distribution, half-life, area under curve, mean residence time, steady state concentration, loading dose, maintenance dose, dose adjustment, bioavailability, bioequivalence, therapeutic drug monitoring, etc.
Multi-compartment models: This chapter introduces the more complex pharmacokinetic models that involve two or more compartments. It explains the equations for two compartment open model, three compartment open model, physiological model, etc.
Non-linear pharmacokinetics: This chapter discusses the situations where the pharmacokinetic parameters are not constant but depend on the drug concentration or dose. It explains the causes, types, models, methods, and implications of non-linear pharmacokinetics.
In-vitro dissolution testing: This chapter describes the importance, principles, apparatuses, methods, specifications, factors, models, correlations, etc. of in-vitro dissolution testing for solid dosage forms.
Application of principles in formulation development: This chapter illustrates the practical application of biopharmaceutics and pharmacokinetics in the design, development, evaluation, and optimization of drug formulations. It also discusses the regulatory requirements and guidelines for bioequivalence studies.
Biostatistics: This chapter introduces the basic concepts and methods of biostatistics, such as descriptive statistics, probability, hypothesis testing, confidence intervals, ANOVA, regression, etc. It also provides practice problems and solutions.
Review questions: This chapter provides a question bank of multiple choice questions, short answer questions, and long answer questions for each chapter of the book.
Conclusion
Biopharmaceutics and Pharmacokinetics by V. Venkateswarlu is a comprehensive and user-friendly book that covers the fundamentals and applications of biopharmaceutics and pharmacokinetics. The book is suitable for students, teachers, researchers, and professionals who want to learn or refresh their knowledge of these subjects. The book is available in pdf format from various online sources.
References:
V. Venkateswarlu. Biopharmaceutics and Pharmacokinetics. PharmaMed Press, 2015.
V. Venkateswarlu. Biopharmaceutics and Pharmacokinetics. B S Publishers, 2004.
Web of Pharma. Biopharmaceutics and Pharmacokinetics V. Venkateswarlu pdf free download. Retrieved from [